The potential of leucosidea sericea against propionibacterium acnes

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dc.contributor.authorSharma, Richa
dc.contributor.authorKishore, Navneet
dc.contributor.authorHussein, Ahmed
dc.date.accessioned2023-06-07T08:02:50Z
dc.date.available2023-06-07T08:02:50Z
dc.date.issued2014
dc.description.abstractThe present study reports on the potential of Leucosidea sericea addressing acne vulgaris. Four known compounds namely phytol acetate, triacontanol, phytol and alpha kosin and one new compound namely, (E)-3,7,11,15-tetramethylheptadec-2-ene-1,17-diol have been isolated for the first time from this plant. The ethanol extract of leaves and one of the isolated compounds, alpha kosin exhibited significant minimum inhibitory concentration (with MIC values 15.7 μg/mL and 1.9 μg/mL, respectively) against acne inducing bacteria, Propionibacterium acnes. Moreover, the transmission electron micrographs showed the efflux of intracellular content of the cells of P. acnes caused by plant extract and alpha kosin. The ethanol extract of L. sericea exhibited significant anti-inflammatory activity by suppressing interleukin 8 (IL 8) and tumour necrosis factor (TNF α) in coculture of human U937 cells and heat killed P. acnes at concentrations of 25.0, 12.5 and 6.2 μg/mL.en_US
dc.identifier.citationSharma, R. et al. (2014). The potential of leucosidea sericea against propionibacterium acnes. Phytochemistry Letters, 7 , 124-129. https://doi.org/10.1016/j.phytol.2013.11.005en_US
dc.identifier.issn1876-7486
dc.identifier.urihttps://doi.org/10.1016/j.phytol.2013.11.005
dc.identifier.urihttp://hdl.handle.net/10566/9052
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectChemistryen_US
dc.subjectAntibacterialen_US
dc.subjectPropionibacterium acnesen_US
dc.subjectSkin diseaseen_US
dc.titleThe potential of leucosidea sericea against propionibacterium acnesen_US
dc.typeArticleen_US

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