Protective effects of asiatic acid in a spontaneous type 2 diabetic mouse model

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dc.contributor.authorSun, Wen
dc.contributor.authorXu, Guangyuan
dc.contributor.authorMatsabisa, Motlalepula
dc.date.accessioned2023-06-07T10:07:36Z
dc.date.available2023-06-07T10:07:36Z
dc.date.issued2017
dc.description.abstractAsiatic acid (AA) has been demonstrated to exhibit anti‑diabetic activity. However, the mechanisms and underlying signaling pathways remain to be elucidated. The present study was performed to confirm the protective effect of AA and demonstrate its ability to regulate the phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase‑3β (GSK‑3β) signaling pathway in db/db mice. Db/db mice fed on a high‑fat diet were used to model diabetes mellitus. Modeled mice were divided randomly into the model control, pioglitazone hydrochloride tablet (PH) and AA groups. Age‑matched C57 BL/6J mice served as normal controls.en_US
dc.identifier.citationSun, W. et al. (2017). Protective effects of asiatic acid in a spontaneous type 2 diabetic mouse model. Molecular Medicine Reports, 16 (2) ,1333-1339. https://doi.org/10.3892/mmr.2017.6684en_US
dc.identifier.issn1791-3004
dc.identifier.urihttps://doi.org/10.3892/mmr.2017.6684
dc.identifier.urihttp://hdl.handle.net/10566/9060
dc.language.isoenen_US
dc.publisherSpandidos Publicationsen_US
dc.subjectMedical scienceen_US
dc.subjectMedicinal plantsen_US
dc.subjectAsiatic aciden_US
dc.subjectHerbal medicineen_US
dc.titleProtective effects of asiatic acid in a spontaneous type 2 diabetic mouse modelen_US
dc.typeArticleen_US

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