Hypoglycaemic activity of biosynthesized copper oxide nanoparticles in alloxan-induced diabetic Wister rats

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dc.contributor.authorUmar, Maimuna Bello
dc.contributor.authorDaniel, Augustine Innalegwu
dc.contributor.authorTijani, Jimoh Oladejo
dc.date.accessioned2023-05-29T07:23:47Z
dc.date.available2023-05-29T07:23:47Z
dc.date.issued2023
dc.description.abstractDiabetes mellitus (DM) is a metabolic disorder that affects the body's ability to produce or use insulin. This study evaluated the hypoglycaemic activity of biosynthesized copper oxide nanoparticles (CuO-NPs) in alloxan-induced diabetic Wister rats. CuO-NPs were synthesized via the green route and characterized using different analytical tools. Diabetes was induced intraperitoneally using 90 mg/kg body weight of alloxan monohydrate in albino rats. Thirty (30) rats were randomly divided into 5 groups of 6 rats each and orally treated for 21 days. Groups I and II were treated with 300 mg/kg bwt Cereus hildmannianus extract and CuO-NPs, respectively. Groups III and IV received 5 mg/kg bwt of Glibenclamide and 2 mL of normal saline, respectively, while Group V was left untreated as the diabetic control. Blood glucose (BG) levels and body weight changes were monitored at 3- and 7- day intervals, respectively, throughout 21-day treatment period. Lipid profiles, enzyme assays and histopathological studies of the liver were also carried out.en_US
dc.identifier.citationUmar, M. B. et al. (2023). Hypoglycaemic activity of biosynthesized copper oxide nanoparticles in alloxan-induced diabetic Wister rats. Endocrinology, Diabetes & Metabolism, 6 (3), e423. https://doi.org/10.1002/edm2.423en_US
dc.identifier.issn2398-9238
dc.identifier.urihttps://doi.org/10.1002/edm2.423
dc.identifier.urihttp://hdl.handle.net/10566/8939
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectBiotechnologyen_US
dc.subjectBiosynthesisen_US
dc.subjectCopper oxide nanoparticlesen_US
dc.subjectDabetes mellitusen_US
dc.subjectHistoarchitectureen_US
dc.titleHypoglycaemic activity of biosynthesized copper oxide nanoparticles in alloxan-induced diabetic Wister ratsen_US
dc.typeArticleen_US

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