Genetic variation and population structure of Botswana populations as identified with AmpFLSTR Identifiler short tandem repeat (STR) loci

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dc.contributor.authorTau, Tiroyamodim
dc.contributor.authorWally, Anthony
dc.contributor.authorFanie, Thokozile Patricia
dc.contributor.authorNgono, Goitseone Lorato
dc.contributor.authorMpoloka, Sununguko Wata
dc.contributor.authorDavison, Sean
dc.contributor.authorD’Amato, María Eugenia
dc.date.accessioned2017-08-07T13:44:44Z
dc.date.available2017-08-07T13:44:44Z
dc.date.issued2017-07-28
dc.description.abstractPopulation structure was investigated in 990 Botswana individuals according to ethno-linguistics, Bantu and Khoisan, and geography (the nine administrative districts) using the Identifiler autosomal microsatellite markers. Genetic diversity and forensic parameters were calculated for the overall population, and according to ethno-linguistics and geography. The overall combined power of exclusion (CPE) was 0.9999965412 and the combined match probability 6,28 × 10−19. CPE was highest for the Khoisan Tuu ethnolinguistic group and the Northeast District at 0.9999582029 and 0.9999922652 respectively. CMP ranged from 6.28 × 10−19 (Khoisan Tuu) to 1,02 × 10−18 (Northwest district). Using pairwise genetic distances (FST), analysis of molecular variance (AMOVA), factorial correspondence analysis (FCA), and the unsupervised Bayesian clustering method found in STRUCTURE and TESS, ethno-linguistics were found to have a greater influence on population structure than geography. FCA showed clustering between Bantu and Khoisan, and within the Bantu. This Bantu sub-structuring was not seen with STRUCTURE and TESS, which detected clustering only between Bantu and Khoisan. The patterns of population structure revealed highlight the need for regional reference databases that include ethno-linguistic and geographic location information. These markers have important potential for bio-anthropological studies as well as for forensic applications.en_US
dc.description.accreditationWeb of Science
dc.identifier.citationTau, T. et al. (2017). Genetic variation and population structure of Botswana populations as identified with AmpFLSTR Identifiler short tandem repeat (STR) loci. Scientific Reports, 7 (6768): 1-12en_US
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10566/3121
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.rightsCopyright Authors. Published articles are licensed under a Creative Commons Attribution License.
dc.source.urihttp://dx.doi.org/10.1038/s41598-017-06365-y
dc.subjectGenetic variationen_US
dc.subjectPopulation structureen_US
dc.subjectBotswanaen_US
dc.subjectAmpFLSTR Identifileren_US
dc.subjectShort tandem repeat (STR)en_US
dc.titleGenetic variation and population structure of Botswana populations as identified with AmpFLSTR Identifiler short tandem repeat (STR) locien_US
dc.typeArticleen_US

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