Isolation and Characterization of Natural Products from Siphonochilus aethiopicus

dc.contributor.advisorMabusela, W.T.
dc.contributor.authorNdiitwani, Dowelani Clement
dc.date.accessioned2023-03-24T11:06:48Z
dc.date.accessioned2024-05-17T08:14:56Z
dc.date.available2023-03-24T11:06:48Z
dc.date.available2024-05-17T08:14:56Z
dc.date.issued2009
dc.description>Magister Scientiae - MScen_US
dc.description.abstractPlants have formed the basis of traditional medicinal systems that have been in existence for thousands of years. Traditional medicines play an important role in protecting, maintaining and restoring the health of people. Therefore, information on folk medicinal uses of plants has in latter times received an intense renewed interest as a source in the search for potential new therapeutic agents. The aim of this study was to isolate and identify natural compounds from Siphonochilus aethiopicus which is a species from the Zingiberaceae family and is one of the most popular medicinal plants in South Africa. This species is used extensively in traditional African medicine for pain relief, asthma, coughs, colds, headaches, dysmenorrhoea and influenza. Extraction of leaves and rhizomes were performed sequentially with hexane, dichloromethane, ethyl acetate, methanol and water. The presences of organic compounds were screened using chromatogtaphic techniques. The screening revealed similarities between the leaves and rhizomes extracts which implies that in order to improve the sustainability of the plants only leaves need to be harvested. All HPLC chromatograms except for the methanol extract of leaves have shown prominent peak. Moreover, the HPLC results confirm that same compounds are present in both leaves and rhizomes. The antimicrobial activity of the rhizome aqueous extract was carried out against Gram positive (Staphylococcus aureus, Mycobacterium smegmatis) and Gram negative (Pseudomonas aeruginosa) bacteria as well as fungus (Candida albicans). GC NMR and MS techniques were used for structural elucidation.en_US
dc.identifier.urihttps://hdl.handle.net/10566/15305
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectSiphonochilus aethiopicusen_US
dc.subjectZinglberaceaeen_US
dc.subjectPhytochemistryen_US
dc.subjectAntimicrobialen_US
dc.subjectTraditional medicineen_US
dc.subjectExtractionen_US
dc.subjectChromatographyen_US
dc.titleIsolation and Characterization of Natural Products from Siphonochilus aethiopicusen_US

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