Inhibition of oxidative stress and skin aging-related enzymes by prenylated chalcones and other flavonoids from helichrysum teretifolium

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dc.contributor.advisorPopoola, Olugbenga K.
dc.contributor.advisorMarnewick, Jeanine L.
dc.contributor.advisorRautenbach, Fanie
dc.contributor.advisorAmeer, Farouk
dc.contributor.advisorIwuoha, Emmanuel I.
dc.contributor.advisorHussein, Ahmed A.
dc.date.accessioned2017-01-30T13:38:20Z
dc.date.available2017-01-30T13:38:20Z
dc.date.issued2015
dc.description.abstractTen flavonoid-related structures viz. heliteretifolin (1), isoxanthohumol (2), 2',4',6'-trihydroxy-3'-prenylchalcone (3), isoglabranin (4), glabranin (5), 7-methoxyisoglabranin (6), quercetin (7), 4'-methoxyquercetin (8), 4'-methoxykaempferol (9) and mosloflavone (10) were isolated from a H. teretifolium methanolic extract and identified. One of them (compound 1) is reported for the first time from a natural source, while compounds 6, 8–10 were isolated for the first time from the genus Helichrysum. The total extract of H. teretifolium showed potent antioxidant activity. When tested for total antioxidant capacity compound 3 possesses moderate biological activity compared to 2, which displayed some of the highest TEAC values (4529.01 ± 2.44; 4170.66 ± 6.72) µM TE/g, respectively. Compounds 7 and 8 demonstrated the highest inhibitory activities on Fe2+-induced lipid peroxidation (IC50 = 2.931; 6.449 µg/mL); tyrosinase (8.092; 27.573) and elastase (43.342; 86.548). Additionally, the total antioxidant capacities measured as FRAP (4816.31 ± 7.42; 3584.17 ± 0.54) µM AAE/g, and ORAC for hydroxyl radical (7.265 ± 0.71; 6.779 ± 3.40) × 106 and peroxyl radical (17.836 ± 2.90; 12.545 ± 5.07) × 103 µM TE/g were also observed for compounds 7 and 8, respectively. In conclusion, H. teretifolium total extract represents a rich source of bioactive constituents with potent antioxidant and moderate anti-tyrosinase and anti-elastase activities that can help to avert accumulation of free radicals in the body, and could therefore be good candidates for the prevention and/or treatment of skin-related conditions, such as aging. This is the first scientific report on the chemical and biological profile of H. teretifolium.en_US
dc.identifier.citationPopoola, O.K. et al. (2015). Inhibition of oxidative stress and skin aging-related enzymes by prenylated chalcones and other flavonoids from helichrysum teretifolium. Molecules, 20(4): 7143-7155en_US
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10566/2504
dc.identifier.urihttp://dx.doi.org/10.3390/molecules20047143
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAll articles published by MDPI are made immediately available worldwide under an open access license
dc.subjectHelichrysum teretifoliumen_US
dc.subjectAnti-tyrosinaseen_US
dc.subjectAnti-elastaseen_US
dc.subjectOxidative stressen_US
dc.subjectAnti-agingen_US
dc.subjectFlavonoidsen_US
dc.titleInhibition of oxidative stress and skin aging-related enzymes by prenylated chalcones and other flavonoids from helichrysum teretifoliumen_US
dc.typeArticleen_US

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