Chemical isolation and electro-chemical characterization of antidiabetic compounds from selected South African lamiaceae plant species

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dc.contributor.advisorIwuoha, Emmanuel
dc.contributor.authorEtsassala, Ninon Geornest Eudes Ronauld
dc.date.accessioned2020-07-13T13:28:48Z
dc.date.accessioned2024-05-13T12:40:51Z
dc.date.available2024-05-13T12:40:51Z
dc.date.issued2020
dc.descriptionPhilosophiae Doctor - PhDen_US
dc.description.abstractDiabetes mellitus (DM), being one of the most common metabolic disorders with an elevated morbidity and mortality rate around the world. It is characterised by deficiency in insulin secretion or degradation of secreted insulin. Many internal and external factors such as oxidative stress, obesity and sedentary lifestyle among others have been suggested as the major causes of these cell alterations. Diabetes I and II are the most common types of diabetes. Treatment of type I requires insulin injection, while type II can be managed using different synthetic antidiabetic agents. However, their effectiveness is limited as a result of low bioavailability, high cost of drug production, and unfavourable side effects. There is a great need to develop alternative and more active antidiabetic drugs from natural sources. Natural products are a well-known source for the discovery of new scaffold for drugs discovery, and South Africa is one of the most important megaflora with high percentage of endemism.en_US
dc.description.embargo2023-12-01
dc.identifier.urihttps://hdl.handle.net/10566/14747
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectDiabetes mellitus (DM)en_US
dc.subjectSouth Africaen_US
dc.subjectTreatmenten_US
dc.subjectLamiaceaeen_US
dc.subjectDiabetesen_US
dc.subjectAntidiabetic drugsen_US
dc.subjectOxidative stressen_US
dc.subjectCape Floristic Regionen_US
dc.titleChemical isolation and electro-chemical characterization of antidiabetic compounds from selected South African lamiaceae plant speciesen_US

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Philosophiae Doctor - PhD (Chemistry)