The potential of chalcone-capped gold nanoparticles for the management of diabetes mellitus

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dc.contributor.authorPearce, Brendon
dc.contributor.authorBenjeddou, Mongi
dc.contributor.authorBotha, Subelia
dc.contributor.authorOmolaja, Akinfenwa, A
dc.contributor.authorOmuruyia, Sylvester, I
dc.contributor.authorBadmus, Jelili, A
dc.contributor.authorIsmail, Enas
dc.contributor.authorMarnewick, Jeanine
dc.contributor.authorEkpob, Okobi, E
dc.contributor.authorHussein, Ahmed, A
dc.date.accessioned2021-09-13T11:26:22Z
dc.date.available2021-09-13T11:26:22Z
dc.date.issued2021-08
dc.description.abstractSearching for new natural bioactive capping agents represent an urgent priority in the green synthesis of metal nanoparticles. Additionaly, the biosaftey of metal nanparticles is a major concern especially in medical applications. Recently, the use of pharmacollogicaly active natural products as capping agents has been deployed to avoid toxic effects during the nanoparticles preparation and to enhance their drugability compared with convential drugs. Helichrysum foetidum is a South African medicinal plant used in folk medicine for the treatment of different human pathologies, and it is known to contain a variety of bioactive compounds. Herein, the total extract and two pure chalcones, helichrysetin and helichrysin, isolated from the same plant were successfully used to synthesize quasi-monodispersed gold nanoparticles in the size range of 2–12 nm. The bio-evaluation of samples indicated that the AuNP/capping agent conjugates are biostable, and have different biological profiles from the total extract/pure compounds. The enzymatic inhibition assays showed significant inhibition by the total extract, helichrysetin and their gold nanoparticles. Interestingly, a similar activity was observed for glucose uptake in HEK293 treated cells. On the other hand, all the tested samples relatively demonstrated no cytotoxicity when tested against the HaCaT keratinocytes. In conclusion, the study demonstrated potential enhancement of glucose uptake in mammalian kidney cells, and inhibition of carbohydrate-hydrolysing enzymes by green synthesized gold nanoparticles of H. foetidum. It also provides a therapeutic appraisal of AuNPs/chalcones conjugate towards the development of antidiabetes drugs derived from H. foetidum and its gold nanoparticles.en_US
dc.identifier.urihttps://doi.org/10.1016/j.surfin.2021.101251
dc.identifier.urihttp://hdl.handle.net/10566/6655
dc.language.isoenen_US
dc.publisherSurfaces and Interfacesen_US
dc.subjectHelichrysum foetidumen_US
dc.subjectChalconesen_US
dc.subjectGold nanoparticlesen_US
dc.subjectBio-reductionen_US
dc.subjectα-glucosidaseen_US
dc.subjectToxicityen_US
dc.subjectGlucose uptakeen_US
dc.titleThe potential of chalcone-capped gold nanoparticles for the management of diabetes mellitusen_US
dc.typeArticleen_US

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