Formulation and clinical translation of inhalable nanomedicines for the treatment and prevention of pulmonary infectious diseases
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Date
2025
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Abstract
Pulmonary infections caused by bacteria, viruses and fungi are a significant global health issue. Inhalation therapies are gaining interest as an effective approach to directly target infected lung sites and nanoparticle-based pulmonary delivery systems are increasingly investigated for this purpose. In this review, we provide an overview of common pulmonary infectious
diseases and review recent work on the application of inhalable nanoparticle-based formulations for pulmonary infectious diseases, the formulation strategies, and the current research for delivering inhalable nanomedicines. We also evaluate the current clinical development status, market landscape, and discuss challenges that impede clinical translation and propose
solutions to overcome these obstacles, highlighting promising opportunities for future advancements in the field. Despite advancements made and products reaching the market, notable gap persists in translational research, with challenges in achieving the target product profile, availability of appropriate in vivo disease models, scale-up, and market related questions,
likely hindering research translation to the clinic.
Description
Keywords
Clinical translation of inhaled nanomedicines, Infectious diseases and nanomedicine, Inhalable nanoparticle, Nanoparticle pulmonary drug delivery, Drug Compounding
Citation
Ahmed, R., Tewes, F., Aucamp, M. and Dube, A., 2025. Formulation and clinical translation of inhalable nanomedicines for the treatment and prevention of pulmonary infectious diseases. Drug Delivery and Translational Research, pp.1-27.