Characterization of four new compounds from protea cynaroides leaves and their tyrosinase inhibitory potential

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dc.contributor.authorYalo, Masande
dc.contributor.authorMakhaba, Masixole
dc.contributor.authorHussein, Ahmed A.
dc.date.accessioned2022-07-05T13:46:34Z
dc.date.available2022-07-05T13:46:34Z
dc.date.issued2022
dc.description.abstractProtea cynaroides (king protea) is a flowering plant that belongs to the Proteaceae family. This multi-stemmed shrub is the national flower of South Africa and has important economic and medicinal values. Traditionally, the main therapeutic benefits of this plant species include the treatment of cancer, bladder, and kidney ailments. There are very limited reports on the isolation of phytochemicals and their biological evaluation from P. cynaroides. In this study, the leaves of P. cynaroides were air-dried at room temperature, powdered, and extracted with 80% methanol followed by solvent fractionation (hexane, dichloromethane, ethyl acetate, and butanol). The ethyl acetate and butanol extracts were chromatographed and afforded four new (1–4) and four known (5–8) compounds, whose structures were characterized accordingly as 3,4-bis(4-hydroxybenzoyl)-1,5-anhydro-D-glucitol (1), 4-hydroxybenzoyl-1,5-anhydro-D-glucitol (2), 2-(hydroxymethyl)-4-oxo-4H-pyran-3-yl-6-O-benzoate-β-D-glucopyranoside (3), 3-hydroxy-7,8-dihydro-β-ionone 3-O-β-D-glucopyranoside (4), 4-hydroxybenzoic acid (5), 1,5-anhydro-D-glucitol (6), 3,4-dihydroxybenzoic acid (7), and 3-hydroxykojic acid (8).en_US
dc.identifier.citationYalo, M. et al. (2022). Characterization of four new compounds from protea cynaroides leaves and their tyrosinase inhibitory potential. Plants, 11(13), 1751. https://doi.org/10.3390/plants11131751en_US
dc.identifier.issn2223-7747
dc.identifier.urihttps://doi.org/10.3390/plants11131751
dc.identifier.urihttp://hdl.handle.net/10566/7559
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectProteaceaeen_US
dc.subjectProtea cynaroidesen_US
dc.subjectPlanten_US
dc.subjectPhytochemistryen_US
dc.subjectTyrosinaseen_US
dc.titleCharacterization of four new compounds from protea cynaroides leaves and their tyrosinase inhibitory potentialen_US
dc.typeArticleen_US

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