Alternative medicine and herbal remedies in the treatment of erectile dysfunction: A systematic review

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dc.contributor.authorLeisegang, Kristian
dc.contributor.authorFinelli, Renata
dc.date.accessioned2021-08-31T17:19:48Z
dc.date.available2021-08-31T17:19:48Z
dc.date.issued2021
dc.description.abstractObjectives: To systematically review and discuss the current evidence from placebo-controlled clinical trials that investigated the use of alternative medicines and herbal remedies in the management of erectile dysfunction (ED). Methods: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)- based systematic review using specific keyword combinations was conducted on the PubMed and Scopus databases. Randomised controlled trials investigating herbal medicine in at least one group and using the International Index of Erectile Function (IIEF) as an outcome in patients primarily diagnosed with ED were included for review. Results: Following the literature search, screening and eligibility analysis, a total of 42 articles were included. The 42 articles were categorised as single herb extractions (n = 14), combination herbal formula (n = 5), combination of herbal formula and non-herbal nutraceuticals (n = 7), non-herbal nutraceuticals (n = 5), acupuncture and moxibustion (n = 2), diet and nutrition (n = 3), exercise (n = 5), and topical treatments (n = 1). Based on the results, Korean ginseng, Pygnogenol and Prelox, Tribulus terrestris, Lepidium meyenii, L-arginine, acupuncture and lifestyle interventions were the more predominantly investigated treatments interventions for ED. Conclusions: Panax ginseng, Pygnogenol, Prelox and Tribulus terrestris have promising evidence as herbal products, alongside L-arginine as a nutritional supplement, for ED based on IIEF outcomes, and warrant further clinical investigation. The mechanisms of action remain unclear, but each of these appears to in part increase nitric oxide synthesis. Importantly, improved diet and exercise should be considered, particularly in patients with obesity or diabetes mellitus.en_US
dc.identifier.citationKristian Leisegang & Renata Finelli (2021) Alternative medicine and herbal remedies in the treatment of erectile dysfunction: A systematic review, Arab Journal of Urology, DOI: 10.1080/2090598X.2021.1926753en_US
dc.identifier.uri10.1080/2090598X.2021.1926753
dc.identifier.urihttp://hdl.handle.net/10566/6570
dc.language.isoenen_US
dc.publisherInforma UK Limited, trading as Taylor & Francis Group.en_US
dc.subjectErectile dysfunctionen_US
dc.subjectalternative medicineen_US
dc.subjectherbal medicineen_US
dc.subjectpanax ginsengen_US
dc.subjecttribulus terrestrisen_US
dc.subjectpygnogenolen_US
dc.titleAlternative medicine and herbal remedies in the treatment of erectile dysfunction: A systematic reviewen_US
dc.typeArticleen_US

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