Determination of seminal oxidation–reduction potential (ORP) as an easy and cost-effective clinical marker of male infertility

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dc.contributor.authorAgarwal, A.
dc.contributor.authorHenkel, Ralf
dc.contributor.authorSharma, Rajan
dc.contributor.authorTadros, N.N.
dc.contributor.authorSabanegh, E.
dc.date.accessioned2017-12-13T11:53:56Z
dc.date.available2017-12-13T11:53:56Z
dc.date.issued2017
dc.description.abstractOxidative stress (OS) is an important contributing factor to male infertility. While previous methods to measure seminal OS are time-consuming and limited to the use of freshly produced semen, oxidation reduction potential (ORP) is easier and quicker to perform and can also be used in frozen semen. Therefore, this study evaluated the clinical utility of ORP as a potential marker of male infertility. ORP was measured in semen samples from 293 patients and 15 fertile controls and categorised according to WHO criteria as normozoospermic, oligozoospermic, asthenozoospermic, teratozoospermic and oligoasthenoteratozoospermic. Receiver operating characteristic (ROC) curves were generated to differentiate these categories. Semen parameters were significantly different when subjects were grouped as control and patients or between the patient and normozoospermic group for concentration and morphology. ORP levels were significantly different between the control and normozoospermic group. When subjects were grouped based on concentration, motility, morphology or a combination of these, the area under the ROC curve, sensitivity, specificity, positive predictive value and cut-off values were significantly different. These differences were significant when combined with ORP and grouped with any two sperm abnormalities. In conclusion, ORP is a quick, easy, cost-effective and reliable marker of semen quality as well as oxidative stress for use in a clinical setting.en_US
dc.identifier.citationAgarwal, A. et al. (2017). Determination of seminal oxidation–reduction potential (ORP) as an easy and cost-effective clinical marker of male infertility. Andrologia, 2017: e12914.en_US
dc.identifier.issn1439-0272
dc.identifier.urihttp://dx.doi.org/10.1111/and.12914
dc.identifier.urihttp://hdl.handle.net/10566/3330
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherWileyen_US
dc.rightsThis is the author-version of the article published online at: http://dx.doi.org/10.1111/and.12914
dc.status.ispeerreviewedTRUE
dc.subjectMale infertilityen_US
dc.subjectOxidation–reduction potentialen_US
dc.subjectSemenen_US
dc.subjectSemen analysisen_US
dc.titleDetermination of seminal oxidation–reduction potential (ORP) as an easy and cost-effective clinical marker of male infertilityen_US
dc.typeArticleen_US

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