Toward elimination of mother–to–child transmission of HIV in South Africa: how best to monitor early infant infections within the Prevention of Mother–to–Child Transmission Program

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dc.contributor.authorSherman, Gayle G.
dc.contributor.authorMazanderani, Ahmad Haeri
dc.contributor.authorBarron, Peter
dc.contributor.authorBhardwaj, Sanjana
dc.contributor.authorNiit, Ronelle
dc.contributor.authorOkobi, Margaret
dc.contributor.authorPuren, Adrian
dc.contributor.authorJackson, Debra J.
dc.contributor.authorGoga, Ameena Ebrahim
dc.date.accessioned2018-10-31T09:28:49Z
dc.date.available2018-10-31T09:28:49Z
dc.date.issued2017
dc.description.abstractBACKGROUNDSouth Africa has utilized three independent data sources to measure the impact of its program for the prevention of mother–to–child transmission (PMTCT) of HIV. These include the South African National Health Laboratory Service (NHLS), the District Health Information System (DHIS), and South African PMTCT Evaluation (SAPMTCTE) surveys. We compare the results of each, outlining advantages and limitations, and make recommendations for monitoring transmission rates as South Africa works toward achieving elimination of mother–to–child transmission (eMTCT). METHODS HIV polymerase chain reaction (PCR) test data, collected between 1 January 2010 to 31 December 2014, from the NHLS, DHIS and SAPMTCTE surveys were used to compare early mother–to–child transmission (MTCT) rates in South Africa. Data from the NHLS and DHIS were also used to compare early infant diagnosis (EID) coverage. RESULTS The age–adjusted NHLS early MTCT rates of 4.1% in 2010, 2.6% in 2011 and 2.3% in 2012 consistently fall within the 95% confidence interval as measured by three SAPMTCTE surveys in corresponding time periods. Although DHIS data over–estimated MTCT rates in 2010, the MTCT rate declines thereafter to converge with age–adjusted NHLS MTCT rates by 2012. National EID coverage from NHLS data increases from around 52% in 2010 to 87% in 2014. DHIS data over–estimates EID coverage, but this can be corrected by employing an alternative estimate of the HIV–exposed infant population. CONCLUSION NHLS and DHIS, two routine data sources, provide very similar early MTCT rate estimates that fall within the SAPMTCTE survey confidence intervals for 2012. This analysis validates the usefulness of routine data sources to track eMTCT in South Africa.en_US
dc.description.accreditationISI
dc.identifier.citationSherman, G.G. et al. (2017). Toward elimination of mother–to–child transmission of HIV in South Africa: how best to monitor early infant infections within the Prevention of Mother–to–Child Transmission Program. Journal of Global Health, 7(1): 010701en_US
dc.identifier.issn2047-2978
dc.identifier.urihttp://dx.doi.org/10.7189/jogh.07.010701
dc.identifier.urihttp://hdl.handle.net/10566/4173
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherEdinburgh University Global Health Societyen_US
dc.rightsThis article is published under a CC-BY license
dc.status.ispeerreviewedTRUE
dc.subjectprevention of mother–to–child transmission (PMTCT)en_US
dc.subjectHIVen_US
dc.subjectEarly infant infectionsen_US
dc.subjectSouth Africaen_US
dc.titleToward elimination of mother–to–child transmission of HIV in South Africa: how best to monitor early infant infections within the Prevention of Mother–to–Child Transmission Programen_US
dc.typeArticleen_US

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