Genome sequence of the tsetse fly (glossina morsitans): vector of African trypanosomiasis

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dc.contributor.authorChristoffels, Alan
dc.contributor.authorObiero, George F.
dc.contributor.authorHarkins, Gordon William
dc.date.accessioned2017-06-29T01:52:41Z
dc.date.available2017-06-29T01:52:41Z
dc.date.issued2014
dc.description.abstractTsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.en_US
dc.description.accreditationISI
dc.identifier.citationChristoffels, A. et al. (2014). Genome sequence of the tsetse fly (glossina morsitans): vector of African trypanosomiasis. Science 344(6182): 380-386en_US
dc.identifier.issn1095-9203
dc.identifier.urihttp://hdl.handle.net/10566/3012
dc.identifier.urihttp://dx.doi.org/10.1126/science.1249656
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.rightsThis is the author-version of the article published online at: http://dx.doi.org/10.1126/science.1249656
dc.status.ispeerreviewedTRUE
dc.subjectGenomeen_US
dc.subjectGenome sequencingen_US
dc.subjectTsetse flyen_US
dc.subjectGlossina morsitansen_US
dc.subjectHuman African trypanosomiasisen_US
dc.titleGenome sequence of the tsetse fly (glossina morsitans): vector of African trypanosomiasisen_US
dc.typeArticleen_US

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Prof. Alan Christoffels