The use of whole blood cell cultures as a model for assessing the effects of SeptilinTM on the immune system.

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dc.contributor.advisorPool, E.J.
dc.contributor.authorHoosen, Mujeeb
dc.date.accessioned2018-08-02T12:27:41Z
dc.date.accessioned2024-11-04T13:15:27Z
dc.date.available2018-08-02T12:27:41Z
dc.date.available2024-11-04T13:15:27Z
dc.date.issued2017
dc.descriptionMagister Scientiae - MSc (Medical BioSciences)en_US
dc.description.abstractIn the past three decades there has been a huge increase in the use of herbal medicine globally. The active principles of these herbal medicines are mostly unknown with supportive evidence for safety and efficacy very rare. SeptilinTM is a phytopharmaceutical formulation which is recommended for the treatment and management of various infections. It has been claimed to have immunomodulatory actions that potentiates the body's immune response. The immunomodulatory activity of SeptilinTM has not been well investigated via appropriate in vitro models. Therefore this study was undertaken to investigate the in vitro effects of SeptilinTM on biomarkers of specific immune pathways by using WBC. Stimulated and unstimulated WBC were incubated with the product. Enzyme linked immunosorbent assays were used to screen for IL-6, IL-10, and IFN? as biomarkers for inflammation, humoral immunity, and cell mediated immunity, respectively. Results show that the presence of SeptilinTM in LPS stimulated WBC has no effect on the release of IL-6 and IFN? production but stimulated IL-10 production. SeptilinTM in unstimulated WBC has no effect on the release of IL-10 and IFN? production but stimulatory effects on IL-6 production.en_US
dc.identifier.urihttps://hdl.handle.net/10566/17294
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectArtemisia afraen_US
dc.subjectCell mediated immunityen_US
dc.subjectCytokinesen_US
dc.subjectHerbal medicinal productsen_US
dc.subjectHuman whole blood cultureen_US
dc.subjectHumoral immunityen_US
dc.subjectInflammationen_US
dc.subjectRAW 264.7 macrophagesen_US
dc.subjectAspalathus linearis (rooibos)en_US
dc.subjectSeptilinTMen_US
dc.titleThe use of whole blood cell cultures as a model for assessing the effects of SeptilinTM on the immune system.en_US
dc.typeThesisen_US

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