Identification of differentially expressed proteins in obese rats fed different high fat diets using proteomics and bioinformatics approaches

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dc.contributor.advisorNdimba, Bongani K.
dc.contributor.advisorMadiehe, Abram M.
dc.contributor.authorGabuza, Kwazikwakhe
dc.date.accessioned2015-02-09T12:35:57Z
dc.date.accessioned2024-05-09T08:19:21Z
dc.date.available2015-02-09T12:35:57Z
dc.date.available2024-05-09T08:19:21Z
dc.date.issued2013
dc.descriptionPhilosophiae Doctor - PhDen_US
dc.description.abstractObesity is a medical condition in which an energy imbalance leads to excessive accumulation of body fat. Obesity leads to a reduction in life expectancy through its association with chronic diseases of lifestyle. The prevalence of obesity is rapidly increasing throughout the world. It is now accepted that most cases of obesity result from an interaction between genetic and environmental factors. This rapid increase in obesity generally leads to an increase in morbidity and mortality from chronic diseases such as cardiovascular disease, type 2 diabetes, osteoarthritis and cancer of which obesity is a risk factor. There is a lack of information in molecular research to explain how obesity predisposes individuals to these diseases. Proteomics is a molecular tool and a set of techniques used to identify changes at protein level from a diseased state. This study aims to identify differentially expressed proteins in serum of obese rats fed different isocaloric diets using proteomics.en_US
dc.identifier.urihttps://hdl.handle.net/10566/13528
dc.language.isoenen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectHigh fat dieten_US
dc.subjectDiet induced obesityen_US
dc.subject2D gelen_US
dc.subjectMALDI TOF MSen_US
dc.subjectProteomicsen_US
dc.subjectCandidate biomarkersen_US
dc.subjectWistar ratsen_US
dc.subjectSerumen_US
dc.subjectWestern bloten_US
dc.subjectDifferentially expressed proteinsen_US
dc.titleIdentification of differentially expressed proteins in obese rats fed different high fat diets using proteomics and bioinformatics approachesen_US

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Philosophiae Doctor - PhD (Biotechnology)