Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature
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Date
2022
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Publisher
MDPI
Abstract
In this review, we have gathered and analyzed the available genetic evidence on the
association between the methylenetetrahydrofolate reductase gene (MTHFR), rs1801133 and the
risk of Hypertension (HTN) in African populations, which was further compared to the global data
evidence. This review was reported following the Preferred Reporting Items for Systematic Reviews
and Meta-Analyses (PRISMA) protocol and Human Genome Epidemiology Network (HuGENet)
guidelines. Literature was retrieved through major search databases, including PubMed, Scopus,
Web of Science, and African Journal Online. We identified 64 potential studies, of which 4 studies
were from the African continent and 60 studies were reported globally. Among the studies conducted
in Africa, only two (n = 2) reported a significant association between the MTHFR (rs1801133) and the
risk of developing HTN. Only one (n = 1) study population was purely composed of black Africans,
while others were of other ethnicities. Among studies conducted in other continents (n = 60), forty seven (n = 47) studies reported a positive association between MTHFR (rs1801133) and the risk of
developing HTN, whereas the remaining studies (n = 14) did not show a significant association.
Available literature suggests an apparent association between rs1801133 and HTN in global regions;
however, such information is still scarce in Africa, especially in the black African population.
Description
Keywords
Hypertension, methylenetetrahydrofolate reductase gene, MTHFR, Africa, genetic variation
Citation
Mabhida, S.E.; Muhamed, B.; Sharma, J.R.; Apalata, T.; Nomatshila, S.; Mabasa, L.; Benjeddou, M.; Masilela, C.; Ziqubu, K.; Shabalala, S.; et al. Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature. Genes 2022, 13, 631. https://doi.org/10.3390/ genes13040631