Evaluation of the effect of polyethylene glycol incorporation on the performance of poly(lactic-co-glycolic acid) nanoparticles

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dc.contributor.advisorDube, Admire
dc.contributor.authorSamkange, Tendai
dc.date.accessioned2018-07-25T11:18:43Z
dc.date.accessioned2024-10-29T13:17:59Z
dc.date.available2018-08-31T22:10:06Z
dc.date.available2024-10-29T13:17:59Z
dc.date.issued2016
dc.descriptionMagister Scientiae - MSc (Pharmaceutical Chemistry)
dc.description.abstractNanoparticle drug delivery is challenged by the binding of proteins in blood which result in their rapid removal from the circulatory system. Nanoparticles engineered to delay protein binding have shown to have extended circulatory times. One such engineering technique is PEGylation, which is the coating of nanoparticles with polyethylene glycol (PEG). PEG shields the nanoparticle from adhesive interactions with proteins. However, the optimal PEG content required to impart this "stealth" property onto poly(lactic-co-glycolic acid) (PLGA) nanoparticles, is unknown. Moreover, the effect of PEGylation on drug release has not been thoroughly investigated.
dc.identifier.urihttps://hdl.handle.net/10566/16349
dc.language.isoen
dc.publisherUniversity of the Western Cape
dc.rights.holderUniversity of the Western Cape
dc.titleEvaluation of the effect of polyethylene glycol incorporation on the performance of poly(lactic-co-glycolic acid) nanoparticles

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