Cytotoxic and cell cycle arrest properties of two steroidal alkaloids isolated from Holarrhena floribunda (G. Don) T. Durand & Schinz leaves

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dc.contributor.authorBadmus, Jelili Abiodun
dc.contributor.authorEkpo, Okobi Eko
dc.contributor.authorHussein, A. A.
dc.date.accessioned2023-03-08T09:27:56Z
dc.date.available2023-03-08T09:27:56Z
dc.date.issued2019
dc.description.abstractThe plant Holarrhena floribunda (H. floribunda; G. Don) is indigenous to sub-Saharan Africa and is traditionally used to treat several ailments. The present study was carried out to isolate and characterize bioactive compounds with anti-proliferative activity present in H. floribunda extracts. Compounds were isolated from H. floribunda using the bioassay-guided fractionation technique of repeated column chromatography and the step-wise application of the MTT reduction assay to assess antiproliferative bioactivity. The structures of the compounds were identified mainly using NMR. The effects of the isolated compounds on the viability, cell cycle and proliferation of human cancer cell lines (MCF-7, HeLa and HT-29) as well as the non-cancerous human fibroblast cell line (KMST-6) were investigated.en_US
dc.identifier.citationBadmus, J. A. et al. (2019). Cytotoxic and cell cycle arrest properties of two steroidal alkaloids isolated from Holarrhena floribunda (G. Don) T. Durand & Schinz leaves. BMC Complementary and Alternative Medicine, 19. https://doi.org/10.1186/s12906-019-2521-9en_US
dc.identifier.issn2662-7671
dc.identifier.urihttps://doi.org/10.1186/s12906-019-2521-9
dc.identifier.urihttp://hdl.handle.net/10566/8553
dc.language.isoenen_US
dc.publisherBMCen_US
dc.subjectSteroidal alkaloidsen_US
dc.subjectBioscienceen_US
dc.subjectCytotoxicityen_US
dc.subjectCell cycleen_US
dc.titleCytotoxic and cell cycle arrest properties of two steroidal alkaloids isolated from Holarrhena floribunda (G. Don) T. Durand & Schinz leavesen_US
dc.typeArticleen_US

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