Application of fundamental techniques for physicochemical characterizations to understand post-formulation performance of pharmaceutical nanocrystalline materials

dc.contributor.authorAucamp, M
dc.contributor.authorWitika, B.A
dc.contributor.authorMweetwa, L.L
dc.date.accessioned2021-05-17T09:06:12Z
dc.date.available2021-05-17T09:06:12Z
dc.date.issued2021
dc.description.abstractNanocrystalline materials (NCM, i.e., crystalline nanoparticles) have become an important class of materials with great potential for applications ranging from drug delivery and electronics to optics. Drug nanocrystals (NC) and nano co-crystals (NCC) are examples of NCM with fascinating physicochemical properties and have attracted significant attention in drug delivery. NCM are categorized by advantageous properties, such as high drug-loading efficiency, good long-term physical stability, steady and predictable drug release, and long systemic circulation time. These properties make them excellent formulations for the efficient delivery of a variety of active pharmaceutical ingredients (API). In this review, we summarize the recent advances in drug NCM-based therapy options. Currently, there are three main methods to synthesize drug NCM, including top-down, bottom-up, and combination methods. The fundamental characterization methods of drug NCM are elaborated. Furthermore, the applications of these characterizations and their implications on the post-formulation performance of NCM are introduced.en_US
dc.identifier.citationAucamp, M. et al. (2021). Application of fundamental techniques for physicochemical characterizations to understand post-formulation performance of pharmaceutical nanocrystalline materials. Crystals. 11(3),310en_US
dc.identifier.issn20734352
dc.identifier.uri10.3390/cryst11030310
dc.identifier.urihttp://hdl.handle.net/10566/6152
dc.language.isoenen_US
dc.publisherMPDIen_US
dc.subjectNanocrystalline materialsen_US
dc.subjectPhysicochemical characterizationen_US
dc.subjectVibrational spectroscopyen_US
dc.subjectCritical quality attributesen_US
dc.subjectX-ray analysisen_US
dc.titleApplication of fundamental techniques for physicochemical characterizations to understand post-formulation performance of pharmaceutical nanocrystalline materialsen_US
dc.typeArticleen_US

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