The association between environmental exposures during childhood and the subsequent development of Crohn's Disease: A score analysis approach

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dc.contributor.authorSabe, Victor Tinashe
dc.contributor.authorBasson, Abigail
dc.contributor.authorJordaan, Esme
dc.contributor.authorMazinu, Mikateko
dc.date.accessioned2017-03-13T07:22:09Z
dc.date.available2017-03-13T07:22:09Z
dc.date.issued2017
dc.description.abstractBackground Environmental factors during childhood are thought to play a role in the aetiology of Crohn's Disease (CD). In South Africa, recently published work based on an investigation of 14 childhood environmental exposures during 3 age intervals (0-5, 6-10 and 11-18 years) has provided insight into the role of timing of exposure in the future development of CD. The 'overlapping' contribution of the investigated variables however, remains unclear. The aim of this study was to perform a post hoc analysis using this data and investigate the extent to which each variable contributes to the subsequent development of CD relative to each aforementioned age interval, based on a score analysis approach. Methods Three methods were used for the score analysis. Two methods employed the subgrouping of one or more (similar) variables (methods A and B), with each subgroup assigned a score value weighting equal to one. For comparison, the third approach (method 0) involved no grouping of the 14 variables. Thus, each variable held a score value of one. Results Results of the score analysis (Method 0) for the environmental exposures during 3 age intervals (0-5, 6-10 and 11-18 years) revealed no significant difference between the case and control groups. By contrast, results from Method A and Method B revealed a significant difference during all 3 age intervals between the case and control groups, with cases having significantly lower exposure scores (approximately 30% and 40% lower, respectively). Conclusion Results from the score analysis provide insight into the 'compound' effects from multiple environmental exposures in the aetiology of CD.en_US
dc.description.accreditationISIen_US
dc.identifier.citationSabe, V.T. et al. (2017). The association between environmental exposures during childhood and the subsequent development of Crohn's Disease: A score analysis approach. PLoS ONE, 12(2): Art. #e0171742en_US
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10566/2618
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0171742
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherPublic Library of Scienceen_US
dc.rights© 2017 Sabe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.status.ispeerreviewedTRUE
dc.subjectEnvironmental exposureen_US
dc.subjectChildhooden_US
dc.subjectChron's diseaseen_US
dc.subjectScore analysisen_US
dc.titleThe association between environmental exposures during childhood and the subsequent development of Crohn's Disease: A score analysis approachen_US
dc.typeArticleen_US

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