Cheminformatic Characterization of Natural Antimicrob al Products for the Development of New Lead Compounds

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dc.contributor.authorEgieyeh, Samuel Ayodele
dc.contributor.authorOselusi, Samson Olaitan
dc.contributor.authorChristoffels, Alan
dc.date.accessioned2021-09-01T08:03:42Z
dc.date.available2021-09-01T08:03:42Z
dc.date.issued2021
dc.description.abstractThe growing antimicrobial resistance (AMR) of pathogenic organisms to currently pre- scribed drugs has resulted in the failure to treat various infections caused by these superbugs. Therefore, to keep pace with the increasing drug resistance, there is a pressing need for novel antimicrobial agents, especially from non-conventional sources. Several natural products (NPs) have been shown to display promising in vitro activities against multidrug-resistant pathogens. Still, only a few of these compounds have been studied as prospective drug candidates. This may be due to the expensive and time-consuming process of conducting important studies on these compounds. The present review focuses on applying cheminformatics strategies to characterize, prioritize, and optimize NPs to develop new lead compounds against antimicrobial resistance pathogens. Moreover, case studies where these strategies have been used to identify potential drug candidates, including a few selected open-access tools commonly used for these studies, are briefly outlined.en_US
dc.identifier.citationOselusi, Samson & Christoffels, Alan & Egieyeh, Samuel. (2021). Cheminformatic Characterization of Natural Antimicrobial Products for the Development of New Lead Compounds. Molecules. 26. 3970. 10.3390/molecules26133970.en_US
dc.identifier.uri10.3390/molecules26133970.
dc.identifier.urihttp://hdl.handle.net/10566/6585
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectantimicrobial resistanceen_US
dc.subjectnatural productsen_US
dc.subjectcheminformaticsen_US
dc.subjecthit prioritizationen_US
dc.subjectdrug-likenessen_US
dc.titleCheminformatic Characterization of Natural Antimicrob al Products for the Development of New Lead Compoundsen_US
dc.typeArticleen_US

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