Quantum dots-amplified electrochemical cytochrome P450 phenotype sensor for tamoxifen, a breast cancer drug

Simple item page
dc.contributor.advisorIwuoha, Emmanuel I.
dc.contributor.authorFeleni, Usisipho
dc.date.accessioned2017-07-28T07:18:55Z
dc.date.accessioned2024-05-13T12:40:28Z
dc.date.available2020-08-31T22:10:05Z
dc.date.available2024-05-13T12:40:28Z
dc.date.issued2017
dc.descriptionPhilosophiae Doctor - PhDen_US
dc.description.abstractBreast cancer is regarded as the most common cancer in South Africa and its rate of occurrence is increasing. About one in every 31 South African women are at the risk of developing breast cancer and early diagnosis and treatment guarantee 90% survival rate. Tamoxifen is the drugs of choice for the treatment of all stages of breast cancer. The drug binds with estrogen receptor (ER) to minimize the transcription of estrogen dependent genes. However, nearly 50% of ER-positive breast cancer patients either become resistant or fail to respond to tamoxifen resulting in a serious clinical challenge in breast cancer management. The Grand Health Challenges of South Africa includes the development of cost effective diagnostic systems suitable for early detection of diseases and drug resistivity for timely invention and better patient management.en_US
dc.identifier.citationFeleni, U. (2017). Quantum dots-amplified electrochemical cytochrome P450 phenotype sensor for tamoxifen, a breast cancer drug. PhD. University of the Western Capeen_US
dc.identifier.urihttps://hdl.handle.net/10566/14690
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectBreast canceren_US
dc.subjectCapping agentsen_US
dc.subjectCyclic voltammetry (CV)en_US
dc.subjectCytochrome P450 enzymesen_US
dc.subjectDifferential pulse voltammetry (DPV)en_US
dc.subjectElectrochemical phenotype sensorsen_US
dc.subjectIndinaviren_US
dc.subjectLimit of detection (LOD)en_US
dc.subjectPalladium tellurideen_US
dc.subjectQuantum dotsen_US
dc.subjectSquare wave voltammetry (SWV)en_US
dc.subjectTamoxifenen_US
dc.titleQuantum dots-amplified electrochemical cytochrome P450 phenotype sensor for tamoxifen, a breast cancer drugen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Feleni_PhD_2017.pdf
Size:
18.09 MB
Format:
Adobe Portable Document Format
Download

Collections

Philosophiae Doctor - PhD (Chemistry)