Understanding and responding to prescribing patterns of sodium valproate-containing medicines in pregnant women and women of childbearing age in Western Cape, South Africa

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dc.contributor.authorCoetzee, Renier
dc.contributor.authorMehta, Ushma C.
dc.contributor.authorSmith, Mariette
dc.date.accessioned2021-01-19T12:38:29Z
dc.date.available2021-01-19T12:38:29Z
dc.date.issued2020
dc.description.abstractGrowing evidence of the teratogenic potential of sodium valproate (VPA) has changed prescribing practices across the globe; however, the impact of this research and the consequent dissemination of a Dear Health Care Professional Letter (DHCPL) in December 2015, recommending avoidance of the teratogen VPA in women of childbearing age (WOCBA) and pregnant women in South Africa, is unknown. We explored trends and reasons for VPA use among pregnant women and WOCBA in the public sector in Western Cape Province from 1 January 2015 to 31 December 2017. Methods: Using the provincial health information exchange that collates routine electronic health data via unique patient identifiers, we analysed clinical and pharmacy records from 2015 to 2017 to determine prescription patterns of VPA and other antiepileptic drug (AED) and mood-stabilising medicine (MSM) use in WOCBA and pregnant women. Senior clinicians and policy makers were consulted to understand the determinants of VPA use. Results: At least one VPA prescription was dispensed to between 8205 (0.79%) and 9425 (0.94%) WOBCA from a cohort of approximately 1 million WOCBA attending provincial health care facilities per year.en_US
dc.identifier.citationCoetzee, R. et al. (2020). Understanding and responding to prescribing patterns of sodium valproate-containing medicines in pregnant women and women of childbearing age in Western Cape, South Africa. Drug Safety. School of Public Health. University of the Western Cape.en_US
dc.identifier.issn1179-1942
dc.identifier.uri10.1007/s40264-020-00987-4
dc.identifier.urihttp://hdl.handle.net/10566/5687
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjectSouth Africaen_US
dc.subjectChildbearing ageen_US
dc.subjectPregnant womenen_US
dc.subjectSodium valproateen_US
dc.subjectWestern Capeen_US
dc.titleUnderstanding and responding to prescribing patterns of sodium valproate-containing medicines in pregnant women and women of childbearing age in Western Cape, South Africaen_US
dc.typeArticleen_US

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