Acylphloroglucinol derivatives from the South African helichrysum niveum and their biological activities

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dc.contributor.advisorPopoola, Olugbenga K.
dc.contributor.advisorMarnewick, Jeanine L.
dc.contributor.advisorRautenbach, Fanie
dc.contributor.advisorIwuoha, Emmanuel I.
dc.contributor.advisorHussein, Ahmed A.
dc.date.accessioned2017-01-30T13:38:20Z
dc.date.available2017-01-30T13:38:20Z
dc.date.issued2015
dc.description.abstractAbstract: Phytochemical investigation of aerial parts of Helichrysum niveum (H. niveum) using different chromatographic methods including semi-preparative HPLC afforded three new (1–3) and six known (4–10) acylphloroglucinols alongside a known dialcohol triterpene (11). The structures of the isolated compounds were characterized accordingly as 1-benzoyl-3 (3-methylbut-2-enylacetate)-phloroglucinol (helinivene A, 1), 1-benzoyl-3 (2S-hydroxyl-3- methylbut-3-enyl)-phloroglucinol (helinivene B, 2), 8- (2-methylpropanone)-3S, 5, 7-trihydroxyl- 2,2-dimethoxychromane (helinivene C, 3), 1-(2-methylbutanone)-4-O-prenyl-phloroglucinol (4), 1-(2-methylpropanone)-4-O-prennyl-phloroglucinol (5), 1-(butanone)-3-prenyl-phloroglucinol (6), 1- (2-methylbutanone)-3-prenyl-phloroglucinol (7), 1-butanone-3- (3-methylbut-2-enylacetate)- phloroglucinol (8), 1-(2-methylpropanone)-3-prenylphloroglucinol (9), caespitate (10), and 3β-24-dihydroxyterexer-14-ene (11). Excellent total antioxidant capacities were demonstrated by helinivenes A and B (1 and 2) when measured as oxygen radicals absorbance capacity (ORAC), ferric-ion reducing antioxidant power (FRAP), trolox equivalent absorbance capacity (TEAC) and including the inhibition of Fe2+-induced lipid peroxidation (IC50 = 5.12 ± 0.90; 3.55 ± 1.92) µg/mL, while anti-tyrosinase activity at IC50 = 35.63 ± 4.67 and 26.72 ± 5.05 µg/mL were also observed for 1 and 2, respectively. This is the first chemical and in vitro biological study on H. niveum. These findings underpin new perspectives for theen_US
dc.identifier.citationPopoola, O.K. et al. (2015). Acylphloroglucinol derivatives from the South African helichrysum niveum and their biological activities. Molecules, 20: 17309-17324en_US
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10566/2503
dc.identifier.urihttp://dx.doi.org/10.3390/molecules200917309
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAll articles published by MDPI are made immediately available worldwide under an open access license
dc.subjectHelichrysum niveumen_US
dc.subjectAsteraceaeen_US
dc.subjectPhloroglucinolsen_US
dc.subjectAntioxidanten_US
dc.subjectAnti-agingen_US
dc.titleAcylphloroglucinol derivatives from the South African helichrysum niveum and their biological activitiesen_US
dc.typeArticleen_US

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