HIV Subtype C Diversity: Analysis of the Relationship of Sequence Diversity to Proposed Epitope Locations

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dc.contributor.advisorHide, Winston
dc.contributor.authorErnstoff, Elana Ann
dc.date.accessioned2022-09-21T09:56:17Z
dc.date.accessioned2024-05-17T07:20:12Z
dc.date.available2022-09-21T09:56:17Z
dc.date.available2024-05-17T07:20:12Z
dc.date.issued2002
dc.description>Magister Scientiae - MScen_US
dc.description.abstractSouthern Africa is facing one of the most serious HIV epidemics. This project contributes to the HIVNET, Network for Prevention Trials cohort for vaccine development. HIV's biology and rapid mutation rate have made vaccine design difficult. We examined HIV-l subtype C diversity and how it relates to CTL epitope location along viral gag sequences. We found a negative correlation between codon sites under positive selection and epitope regions; suggesting epitope regions are evolutionarily conserved. It is possible that detected due to the reference regions, yet fail to be viral population. To test if CTL clustering is an we calculated differences between the gag codons and the a weak negative correlation, suggesting epitopes in less conserved regions maybe evading detection. Locating conserved and optimal epitopes that can be recognized by CTLs is essential for the design of vaccine reagents.en_US
dc.identifier.urihttps://hdl.handle.net/10566/15242
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectHIVen_US
dc.subjectSubtype Cen_US
dc.subjectCytotoxic T Lymphoctyes (CTL)en_US
dc.subjectHuman Leukocyte Antigen (HLA)en_US
dc.subjectPositive Selectionen_US
dc.subjectMaximum Likelihooden_US
dc.subjectPhylogeneticen_US
dc.subjectImmunologyen_US
dc.subjectEvolutionen_US
dc.subjectSouthern Africaen_US
dc.titleHIV Subtype C Diversity: Analysis of the Relationship of Sequence Diversity to Proposed Epitope Locationsen_US

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