Next generation precision medicine: Crispr-mediated genome editing for the treatment of neurodegenerative disorders

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dc.contributor.authorMentor, Shireen
dc.date.accessioned2023-01-11T07:44:20Z
dc.date.available2023-01-11T07:44:20Z
dc.date.issued2019
dc.description.abstractDespite significant advancements in the field of molecular neurobiology especially neuroinflammation and neurodegeneration, the highly complex molecular mechanisms underlying neurodegenerative diseases remain elusive. As a result, the development of the next generation neurotherapeutics has experienced a considerable lag phase. Recent advancements in the field of genome editing offer a new template for dissecting the precise molecular pathways underlying the complex neurodegenerative disorders. We believe that the innovative genome and transcriptome editing strategies offer an excellent opportunity to decipher novel therapeutic targets, develop novel neurodegenerative disease models, develop neuroimaging modalities, develop next-generation diagnostics as well as develop patient-specific precision-targeted personalized therapies to effectively treat neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Amyotrophic lateral sclerosis, Frontotemporal dementia etcen_US
dc.identifier.citationRaikwar, S. P. et al. (2019). Next Generation Precision Medicine: CRISPR-mediated Genome Editing for the Treatment of Neurodegenerative Disorders. J Neuroimmune Pharmacol 14, 608–641 (2019). https://doi.org/10.1007/s11481-019-09849-yen_US
dc.identifier.issn1557-1890
dc.identifier.urihttp://hdl.handle.net/10566/8263
dc.language.isoen_USen_US
dc.publisherSpringerlinken_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectAmyotrophic lateral sclerosisen_US
dc.subjectCRISPRen_US
dc.subjectFrontotemporal dementiaen_US
dc.subjectgenome editingen_US
dc.titleNext generation precision medicine: Crispr-mediated genome editing for the treatment of neurodegenerative disordersen_US
dc.typeArticleen_US

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