Alkaloids: Therapeutic Potential against Human Coronaviruses
| dc.contributor.author | Fielding, Burtram Clinton | |
| dc.contributor.author | da Silva Maia Bezerra Filho, Carlos | |
| dc.contributor.author | Ismail, Nasser S.M. | |
| dc.date.accessioned | 2020-12-11T07:56:26Z | |
| dc.date.available | 2020-12-11T07:56:26Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide array of pathologies. Some alkaloids have antiviral activity and/or have been used as prototypes in the development of synthetic antiviral drugs. In this study, eleven anti-coronavirus alkaloids were identified from the scientific literature and their potential therapeutic value against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is discussed. In this study, in silico studies showed an affinity of the alkaloids for binding to the receptor-binding domain of the SARS-CoV-2 spike protein, putatively preventing it from binding to the host cell. Lastly, several mechanisms for the known anti-coronavirus activity of alkaloids were discussed, showing that the alkaloids are interesting compounds with potential use as bioactive agents against SARS-CoV-2. | en_US |
| dc.identifier.citation | Fielding, B. C. et al. (2020). Alkaloids: Therapeutic Potential against Human Coronaviruses. Molecules (Basel, Switzerland),25(23) | en_US |
| dc.identifier.issn | 1420-3049 | |
| dc.identifier.uri | http://hdl.handle.net/10566/5503 | |
| dc.language.iso | en | en_US |
| dc.publisher | MPDI | en_US |
| dc.subject | COVID-19 | en_US |
| dc.subject | Natural products | en_US |
| dc.subject | Antiviral drug | en_US |
| dc.subject | SARS-CoV | en_US |
| dc.subject | MERS-CoV | en_US |
| dc.title | Alkaloids: Therapeutic Potential against Human Coronaviruses | en_US |
| dc.type | Article | en_US |