Synthesis, characterization and antibacterial activity studies of new 2‑pyrral‑L‑amino acid Schif base palladium (II) complexes.

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dc.contributor.authorNyawade, Eunice A.
dc.date.accessioned2021-04-20T15:00:28Z
dc.date.available2021-04-20T15:00:28Z
dc.date.issued2020
dc.description.abstractThree new 2-pyrral amino acid Schif base palladium (II) complexes were synthesized, characterized and their activity against six bacterial species was investigated. The ligands: Potassium 2-pyrrolidine-L-methioninate (L1), Potassium 2-pyrrolidine-L-histidinate (L2) and Potassium 2-pyrrolidine-L-tryptophanate (L3) were synthesized and reacted with dichloro(1,5- cyclooctadiene)palladium(II) to form new palladium (II) complexes C1, C2 and C3, respectively. 1 NMR, FTIR, UV–Vis,elemental analysis and conductivity measurements were used to characterize the products. The antibacterial activities of the compounds were evaluated against Gram-positive Staphylococcus aureus (S. aureus, ATCC 25923), methicillin-resistant Staphylococcus aureus (MRSA, ATCC 33591), Staphylococcus epidermidis (S. epidermidis, ATCC 12228) and Streptococcus pyogenes (S. pyogenes, ATCC 19615) and, gram-negative Pseudomonas aeruginosa (P. aeruginosa, ATCC 27853) and Klebsiella pneumoniae (K. pneumoniae, ATCC 13883) using the agar well difusion assay and microtitre plate serial dilution method. The palladium complexes were active against the selected bacteria with the imidazole ring containing complex C2 and indole heterocyclic ring containing complex C3 showing the highest activity.en_US
dc.identifier.citationNyawade, Eunice A. (2020) Chemical Papers. Synthesis, characterization and antibacterial activity studies of new 2‑pyrral‑L‑amino acid Schif base palladium (II) complexes.en_US
dc.identifier.uridoi: 10.1007/s11696-019-00986-5
dc.identifier.urihttp://hdl.handle.net/10566/6081
dc.language.isoenen_US
dc.publisherChemical Papersen_US
dc.subjectSchif basesen_US
dc.subjectAntibacterialen_US
dc.subjectPalladiumen_US
dc.subjectChelatesen_US
dc.subjectAmino acidsen_US
dc.subjectPyrroleen_US
dc.subjectImidazoleen_US
dc.subjectIndoleen_US
dc.titleSynthesis, characterization and antibacterial activity studies of new 2‑pyrral‑L‑amino acid Schif base palladium (II) complexes.en_US
dc.typeArticleen_US

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