Inhibition of bacteria associated with wound infection by biocompatible green synthesized gold nanoparticles from South African plant extracts

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dc.contributor.authorElbagory, Abdulrahman M.
dc.contributor.authorMeyer, Mervin
dc.contributor.authorCupido, Christopher N.
dc.contributor.authorHussein, Ahmed A.
dc.date.accessioned2017-12-06T09:10:39Z
dc.date.available2017-12-06T09:10:39Z
dc.date.issued2017
dc.description.abstractUnlike conventional physical and chemical methods, the biogenic synthesis of gold nanoparticles (GNPs) is considered a green and non-toxic approach to produce biocompatible GNPs that can be utilized in various biomedical applications. This can be achieved by using plant-derived phytochemicals to reduce gold salt into GNPs. Several green synthesized GNPs have been shown to have antibacterial effects, which can be applied in wound dressings to prevent wound infections. Therefore, the aim of this study is to synthesize biogenic GNPs from the South African Galenia africana and Hypoxis hemerocallidea plants extracts and evaluate their antibacterial activity, using the Alamar blue assay, against bacterial strains that are known to cause wound infections. Additionally, we investigated the toxicity of the biogenic GNPs to non-cancerous human fibroblast cells (KMST-6) using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay. In this paper, spherical GNPs, with particle sizes ranging from 9 to 27 nm, were synthesized and fully characterized. The GNPs from H. hemerocallidea exhibited antibacterial activity against all the tested bacterial strains, whereas GNPs produced from G. africana only exhibited antibacterial activity against Pseudomonas aeruginosa. The GNPs did not show any significant toxicity towards KMST-6 cells, which may suggest that these nanoparticles can be safely applied in wound dressings.en_US
dc.identifier.citationElbagory, A.m. et al. (2017). Inhibition of bacteria associated with wound infection by biocompatible green synthesized gold nanoparticles from South African plant extracts. Nanomaterials, 7: 417en_US
dc.identifier.issn2079-4991
dc.identifier.urihttp://dx.doi.org/10.3390/nano7120417
dc.identifier.urihttp://hdl.handle.net/10566/3300
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherMDPIen_US
dc.rights© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.status.ispeerreviewedTRUE
dc.subjectGold nanoparticlesen_US
dc.subjectGreen nanotechnologyen_US
dc.subjectGalenia africanaen_US
dc.subjectHypoxis hemerocallideaen_US
dc.subjectAntibacterial activityen_US
dc.subjectAlamar blueen_US
dc.subjectMTTen_US
dc.subjectHRTEMen_US
dc.titleInhibition of bacteria associated with wound infection by biocompatible green synthesized gold nanoparticles from South African plant extractsen_US
dc.typeArticleen_US

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