Comparison of the sutherlandioside B levels in two commercially available Sutherlandia frutescence preparations and the effect of elevated temperature and humidity on these levels

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dc.contributor.advisorSyce, James A.
dc.contributor.authorJoseph, Ashton Edward
dc.contributor.otherSchool of Pharmacy
dc.contributor.otherFaculty of Community and Health Sciences
dc.date.accessioned2013-10-28T09:00:43Z
dc.date.accessioned2024-05-15T07:43:09Z
dc.date.available2011/03/04 13:11
dc.date.available2011/03/04
dc.date.available2013-10-28T09:00:43Z
dc.date.available2024-05-15T07:43:09Z
dc.date.issued2009
dc.descriptionMagister Pharmaceuticae - MPharmen_US
dc.description.abstractSutherlandia frutescens (tribe Galegeae, Fabaceae), is a popular medicinal plant traditionally used in South Africa. In 2000, a company called Phyto Nova (Pty) Ltd. initiated large-scale cultivation and contract manufacturing of tablets, made from the powdered herb (i.e. thin stems and leaves). Most of these commercial Sutherlandia solid dosage forms are made from the dried leaf powder but recently a new product, viz. Promune™ capsules, made from a freeze-dried aqueous extract, came on the market and was claimed to be “better” as it mimics the traditional tea. However, the pharmaceutical quality and stability of these preparations have not yet been investigated. The objectives of this study were firstly, to develop a validated stability-indicating HPLC assay for sutherlandioside B (SU-B); secondly, to compare the SU-B levels in the two commercially available Sutherlandia products viz, the Phyto Nova Sutherlandia SU1™ tablet and the Promune™ capsule, and, thirdly, to determine the effect of elevated temperature and humidity as well as acid hydrolysis on the SU-B levels in these two products.en_US
dc.description.countrySouth Africa
dc.identifier.urihttps://hdl.handle.net/10566/15197
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectSutherlandioside B (SU-B or SU1)en_US
dc.subjectSutherlandia frutescensen_US
dc.subjectPhyto Nova Sutherlandia SU1 tabletsen_US
dc.subjectPromune™en_US
dc.subjectHPLC assayen_US
dc.subjectCycloartane glycosideen_US
dc.subjectHerbal solid dosage formsen_US
dc.subjectElevated temperatureen_US
dc.subjectRelative humidityen_US
dc.subjectAcid hydrolysisen_US
dc.titleComparison of the sutherlandioside B levels in two commercially available Sutherlandia frutescence preparations and the effect of elevated temperature and humidity on these levelsen_US
dc.typeThesisen_US

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