Identification of coding variants associated with familial systemic lupus erythematosus through whole exome sequencing
| dc.contributor.advisor | Tiffin, Nicki | |
| dc.contributor.author | van Vuuren, Larry Peter | |
| dc.date.accessioned | 2018-07-30T10:13:09Z | |
| dc.date.accessioned | 2024-05-17T07:57:56Z | |
| dc.date.available | 2018-08-31T22:10:06Z | |
| dc.date.available | 2024-05-17T07:57:56Z | |
| dc.date.issued | 2016 | |
| dc.description | Philosophiae Doctor - PhD (Bioinformatics) | |
| dc.description.abstract | Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by the production of a wide range of autoantibodies directed against selfantigens. SLE can influence almost any organ system and its appearance and course are highly varied, ranging from remission to disease flare. SLE demonstrates a variety of constitutional symptoms, such as the skin, musculoskeletal and mild hematologic involvement. On the other hand, some patients present with primarily hematologic, renal or neuropsychiatric manifestations. | |
| dc.identifier.uri | https://hdl.handle.net/10566/15284 | |
| dc.language.iso | en | |
| dc.publisher | University of the Western Cape | |
| dc.rights.holder | University of the Western Cape | |
| dc.title | Identification of coding variants associated with familial systemic lupus erythematosus through whole exome sequencing |
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