Novel phages of healthy skin metaviromes from South Africa
| dc.contributor.author | van Zyl, Leonardo Joaquim | |
| dc.contributor.author | Abrahams, Yoonus | |
| dc.contributor.author | Stander, Emily Amor | |
| dc.contributor.author | Kirby-McCollough, Bronwyn | |
| dc.contributor.author | Jourdain, Roland | |
| dc.contributor.author | Clavaud, Cécile | |
| dc.contributor.author | Breton, Lionel | |
| dc.contributor.author | Trindade, Marla | |
| dc.date.accessioned | 2018-08-21T13:22:16Z | |
| dc.date.available | 2018-08-21T13:22:16Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Recent skin metagenomic studies have investigated the harbored viral diversity and its possible influence on healthy skin microbial populations, and tried to establish global patterns of skin-phage evolution. However, the detail associated with the phages that potentially play a role in skin health has not been investigated. While skin metagenome and -metavirome studies have indicated that the skin virome is highly site specific and shows marked interpersonal variation, they have not assessed the presence/absence of individual phages. Here, we took a semi-culture independent approach (metaviromic) to better understand the composition of phage communities on skin from South African study participants. Our data set adds over 130 new phage species of the skin to existing databases. We demonstrated that identical phages were present on different individuals and in different body sites, and we conducted a detailed analysis of the structural organization of these phages. We further found that a bacteriophage related to the Staphylococcus capitis phage Stb20 may be a common skin commensal virus potentially regulating its host and its activities on the skin | en_US |
| dc.identifier.citation | van Zyl, L.J. et al. (2018). Novel phages of healthy skin metaviromes from South Africa. Scientific Reports, 8: 12265 | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1038/s41598-018-30705-1 | |
| dc.identifier.uri | http://hdl.handle.net/10566/3959 | |
| dc.language.iso | en | en_US |
| dc.privacy.showsubmitter | FALSE | |
| dc.publisher | Nature Publishing Group | en_US |
| dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |
| dc.status.ispeerreviewed | TRUE | |
| dc.subject | Healthy skin | en_US |
| dc.subject | Metaviromes | en_US |
| dc.subject | Viral diversity | en_US |
| dc.subject | South Africa | en_US |
| dc.title | Novel phages of healthy skin metaviromes from South Africa | en_US |
| dc.type | Article | en_US |