Green synthesis and characterization of gold nanoparticles from capparis sepiaria-tabernaemontana elegans cocktail and investigation of their biological effects in vitro.
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Date
2024
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University of the Western Cape
Abstract
Wounds have a significant impact on the global healthcare system, adding heavy load on the economy and society. therefore, there is an urgent need to develop treatments that can facilitate rapid wound healing. to make matters worse wound infection by antimicrobial-resistant bacteria may result in prolonged debility of the patient and increased healthcare costs. avoidance of the development of antimicrobial resistance therefore needs increasing attention in the management of patients, with chronic wound infection. nanotechnology presents a groundbreaking method for synthesizing biocompatible nanomaterials (nms), revolutionizing wound healing with soft, flexible dressings that possess antimicrobial properties, gas barrier, and absorbency. these nms might fall into two categories: those with inherent wound-healing properties and those serving as delivery vehicles for therapeutic agents. gold nanoparticles (aunps) have more consideration due to their stability, oxidation resistance, electrical and optical properties. this study reports on the green synthesis and characterization of aunps synthesized using an aqueous extract of capparis sepiariatabernaemontana elegans (cste) and the investigation antibacterial and wound healing effects of the cste-aunps against amr pathogens, such as staphylococcus aureus, methicillin-resistant staphylococcus aureus, escherichia coli, and pseudomonas aeruginosa. wound healing properties of cste-aunps was also investigated using kmst-6 (fibroblast) cell line.
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Keywords
Wound Infections, Wound Healing, Antimicrobial Resistance, Nanotechnology, Gold Nanoparticles (Aunps)