DDESC: Dragon database for exploration of sodium channels in human

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dc.contributor.authorSagar, Sunil
dc.contributor.authorKaur, Mandeep
dc.contributor.authorDawe, Adam
dc.contributor.authorSeshadri, Sundararajan V.
dc.contributor.authorChristoffels, Alan
dc.contributor.authorSchaefer, Ulf
dc.contributor.authorRadovanovic, Aleksander
dc.contributor.authorBajic, Vladimir B.
dc.date.accessioned2015-10-28T13:53:54Z
dc.date.available2015-10-28T13:53:54Z
dc.date.issued2008
dc.description.abstractSodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic disorders such as febrile epilepsy, Brugada syndrome, ventricular fibrillation, long QT syndrome, or channelopathy associated insensitivity to pain. In spite of these significant effects that sodium channel proteins/genes could have on human health, there is no publicly available resource focused on sodium channels that would support exploration of the sodium channel related information. We report here Dragon Database for Exploration of Sodium Channels in Human (DDESC), which provides comprehensive information related to sodium channels regarding different entities, such as "genes and proteins", "metabolites and enzymes", "toxins", "chemicals with pharmacological effects", "disease concepts", "human anatomy", "pathways and pathway reactions" and their potential links. DDESC is compiled based on text- and data-mining. It allows users to explore potential associations between different entities related to sodium channels in human, as well as to automatically generate novel hypotheses. DDESC is first publicly available resource where the information related to sodium channels in human can be explored at different levels.en_US
dc.description.sponsorshipDST/NRF Research grant 64751 National Bioinformatics Network grants Claude Leon Foundationen_US
dc.identifier.citationBajic, V. B. et al. (2008). DDESC: Dragon database for exploration of sodium channels in human. BMC Genomics, 9:622
dc.identifier.urihttp://hdl.handle.net/10566/1929
dc.language.isoenen_US
dc.privacy.showsubmitterfalse
dc.publisherBMC Canceren_US
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttp://dx.doi.org/10.1186/1471-2164-9-622
dc.status.ispeerreviewedfalse
dc.subjectSodium channels
dc.subjectGenetic disorders
dc.subjectParoxysmal extreme pain disorder (PEPD)
dc.subjectCardiac rhythm
dc.subjectDrug design
dc.titleDDESC: Dragon database for exploration of sodium channels in humanen_US
dc.typeArticleen_US

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