Total antioxidant capacity—Relevance, methods and clinical implications

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dc.contributor.authorGupta, Sajal
dc.contributor.authorFinelli, Renata
dc.contributor.authorHenkel, Ralf
dc.date.accessioned2020-11-17T12:55:13Z
dc.date.available2020-11-17T12:55:13Z
dc.date.issued2020
dc.description.abstractOxidative stress is pre‐empted by an adequate level of antioxidants, which scavenge oxidants when they are produced in excess by different sources, including leukocytes and immature spermatozoa. Enzymatic antioxidants, such as superoxide dismutase, catalase and glutathione peroxidase, and several non‐enzymatic antioxidants (proteins, vitamins and minerals), working as oxidant scavengers and cofactors of enzymatic antioxidants have been identified in seminal plasma. The total antioxidant capacity (TAC) is a diagnostic test that can be utilised in the male infertility workup. TAC measures the amount of total antioxidants in seminal plasma. Therefore, it provides an assessment of the reductive potential in seminal plasma. Several studies have investigated the diagnostic application of TAC in various andrology conditions. There is substantial evidence in the literature to show that infertile patients have lower seminal TAC in comparison with fertile men. Moreover, there is a positive correlation between TAC and seminal parameters, such as sperm concentration, motility and morphology. Evaluation of TAC together with reactive oxygen species (ROS) and sperm DNA fragmentation index (DFI) may be beneficial in the diagnosis of male infertility.en_US
dc.description.urihttps://doi.org/10.1111/and.13743
dc.identifier.citationHenkel, . (2020). The role of infections and leukocytes in male infertility. Andrologia:e13743.en_US
dc.identifier.issn03034569
dc.identifier.urihttp://hdl.handle.net/10566/5442
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.subjectAntioxidantsen_US
dc.subjectMale infertilityen_US
dc.subjectOxidative stressen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectSpermatozoaen_US
dc.titleTotal antioxidant capacity—Relevance, methods and clinical implicationsen_US
dc.typeArticleen_US

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