2-Arylnaphthoquinone analogues: Potential anti-TB and pro-apoptotic agents

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dc.contributor.authorGreen, Ivan R
dc.contributor.authorSagar, Sunil
dc.contributor.authorSwigelaar, Wendell
dc.date.accessioned2023-02-09T09:21:06Z
dc.date.available2023-02-09T09:21:06Z
dc.date.issued2011
dc.description.abstractA useful library of substituted 2-arylnaphthoquinones prepared by reaction between the corresponding bromonaphthoquinones and arylboronic acids via Suzuki-Miyaura protocols has been established. Conversion of some of the products into new analogues was effected. The bisnaphthoquinone disospyrin 1 comprises two 7-methyljuglone units linked between C2 and C6. 1,2 Antimycobacterial activity studies performed on diospyrin 1 alerted the scientific community to the potential importance of this natural product3 which was soon followed by its first published synthesis by Yoshida and Mori in the same year.4 Subsequent studies, which included the synthesis and evaluation of related analogues of diospyrin 1 demonstrated the potential of this basic scaffold to be considered as an integral aspect for good antimycrobacterial activity.en_US
dc.identifier.issnARKAT USA
dc.identifier.urihttps://doi.org/10.3998/ark.5550190.0012.a16
dc.identifier.urihttp://hdl.handle.net/10566/8392
dc.language.isoenen_US
dc.publisherGreen, I. R. et al. (2011). 2-Arylnaphthoquinone analogues: Potential anti-TB and pro-apoptotic agents. ARKIVOC, (x), 192-212. https://doi.org/10.3998/ark.5550190.0012.a16en_US
dc.subjectBromonaphthoquinonesen_US
dc.subjectNaphthylboronic acidsen_US
dc.subjectDemethylationen_US
dc.subjectOxidationen_US
dc.subjectChemistryen_US
dc.subjectTuberculosisen_US
dc.title2-Arylnaphthoquinone analogues: Potential anti-TB and pro-apoptotic agentsen_US
dc.typeArticleen_US

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