Chemical and biological evaluation of palythoa tuberculosa collected from the red sea
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Date
2015
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of the Western Cape
Abstract
A chemical study on the total extract of the zoanthid Palythoa tuberculosa, collected
from the Red Sea, resulted in the isolation of seven polyhydroxylated sterols viz:
palysterols A-G, six of which are new. Their chemical structures were elucidated on the basis of their 1D and 2D NMR and MS spectroscopic data. Palysterols B and G
demonstrated cytotoxic activity on three human cancer cell lines (MCF-7, HeLa, and HT- 29). Palysterol G, in particular, was able to induce apoptosis in breast adenocarcinoma(MCF-7) cells
Description
Masters of Science
Keywords
Marine natural product, Red Sea, Palythoa tuberculosa, Polyhydroxylated sterols, Cytotoxicity, Apoptosis