Variant-specific introduction and dispersal dynamics of SARS-CoV-2 in New York City – from Alpha to Omicron

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dc.contributor.authorDellicour, Simon
dc.contributor.authorHong, Samuel L.
dc.contributor.authorHarkins, Gordon W.
dc.date.accessioned2023-05-30T11:53:32Z
dc.date.available2023-05-30T11:53:32Z
dc.date.issued2023
dc.description.abstractSince the latter part of 2020, SARS-CoV-2 evolution has been characterised by the emergence of viral variants associated with distinct biological characteristics. While the main research focus has centred on the ability of new variants to increase in frequency and impact the effective reproductive number of the virus, less attention has been placed on their relative ability to establish transmission chains and to spread through a geographic area. Here, we describe a phylogeographic approach to estimate and compare the introduction and dispersal dynamics of the main SARS-CoV-2 variants – Alpha, Iota, Delta, and Omicron – that circulated in the New York City area between 2020 and 2022. Notably, our results indicate that Delta had a lower ability to establish sustained transmission chains in the NYC area and that Omicron (BA.1) was the variant fastest to disseminate across the study area. The analytical approach presented here complements non-spatially-explicit analytical approaches that seek a better understanding of the epidemiological differences that exist among successive SARS-CoV-2 variants of concernen_US
dc.identifier.citationDellicour, S. et al. (2023). Variant-specific introduction and dispersal dynamics of SARS-CoV-2 in New York City – from Alpha to Omicron. PLoS pathogens, 19(4), e1011348. https://doi.org/10.1371/journal.ppat.1011348en_US
dc.identifier.issn1553-7374
dc.identifier.urihttps://doi.org/10.1371/journal.ppat.1011348
dc.identifier.urihttp://hdl.handle.net/10566/8964
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.subjectCovid-19en_US
dc.subjectPublic healthen_US
dc.subjectBioinfomaticsen_US
dc.subjectNew Yorken_US
dc.subjectPhylogeographyen_US
dc.subjectPhylogeneticsen_US
dc.titleVariant-specific introduction and dispersal dynamics of SARS-CoV-2 in New York City – from Alpha to Omicronen_US
dc.typeArticleen_US

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