(University of the Western Cape, 2022) Mogakane, Khomotso Lesedi; Upton, Edward
Serum Creatinine (SCr) is the most commonly used and cost effective
biomarker used to quantify estimated glomerular filtration rate. However, creatinine is
affected by anthropometric parameters such as muscle mass, age and gender. Cystatin-C
(CysC) is a low molecular weight protein which is freely filtered through the
glomerulus. It has been said to be as accurate as plasma creatinine and is independent of
limitations derived from anthropometric parameters. CysC can also be determined
through point of care devices which do not require the phlebotomy or experienced
laboratory personnel for its use. There have also been correlations noted in CysC serum
concentrations and cardiovascular risk assessment.