Browsing by Author "Xulu Bheki"

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    Investigation of the coordination chemistry, biomolecular interactions, and cytotoxicity of heterocyclic carboxamide manganese(II) complexes
    (Wiley-VCH GmbH, 2025) Moabelo Koena; Meyer Mervin; Tsaulwayo Nokwanda; Xulu Bheki
    For the past few decades, platinum-based compounds notably cisplatin have been the most commonly used in metal-based anti-cancer treatment.[1,2] Despite the success of cisplatin, it has several drawbacks such as side effects, poor solubility, and acquired drug resistance, thus limiting its efficacy. [3,4] These negative attributes of cisplatin have germinated research interests in the design and development of alternative nonplatinum metallo-drugs such as ruthenium, iridium, osmium, palladium, and manganese. [5–7] Compared to the extensive reports on noble metals such as ruthenium and palladium, there are few reports on these of manganese compounds as anticancer agents. [8]