Browsing by Author "WILLIAMS, LETOYA SHEILA"

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    Biogenic silver nanoparticles synthesized using eucomis autumnalis bulb aqueous extract, their characterization and in vitro antibacterial activity
    (University of the Western Cape, 2023) WILLIAMS, LETOYA SHEILA
    Antimicrobial resistance (AMR) is a growing global problem that poses a significant threat to public health. AMR arises when microorganisms become resistant to drugs that were initially designed to kill them. The application of antibiotics has proven effective in eliminating or inhibiting the growth of harmful microorganisms. Conversely, the primary cause of AMR is overprescribing and the misuse of antibiotics which is further increased by a reduced novel antibiotics discovery rate. AMR bacteria lead to hard-to-treat infections, causing longer hospital stays and higher healthcare costs, and is associated with a substantial risk of morbidity and mortality. Consequently, the development of infections caused by multi-drug resistant (MDR) microorganisms has resulted in a considerable reduction in the number of effective treatment options available. Thus, novel therapies are urgently required, considering the ineffectiveness of current therapy, moreover, further exacerbated by a reduced discovery rate of novel antibiotics. Alternative strategies are therefore urgently needed to treat AMR bacterial infections.