Browsing by Author "Tanga, Sandrine"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
Item Design of a thermoresponsive hydrogel for enhanced intratumoral permeation of a chemotherapeutic agent in oral squamous cell carcinoma(University of the Western Cape, 2023) Tanga, Sandrine; Aucamp, MariqueIntroduction: Oral squamous cell carcinoma is the most common and aggressive cancer occurring in the oral cavity. Intravenous chemotherapy remains a pivotal part of treatment for the disease; however, these drugs cause debilitating systemic side effects and are unable to permeate into the deep compact layers of tumorous tissue cells. Herein, the intratumoral delivery of doxorubicin using a novel hydrogel blend, of chitosan/k-carrageenan and PluronicTM F127, for a rapid solution-to-gel thermoresponsive transition at 37 °C is proposed to achieve tumour-specific delivery and controlled drug release. For enhanced permeation, a novel monoterpene – limonene with high lipophilicity and anti-cancer effect is combined with the hydrogel system.