Browsing by Author "Sagar, Sunil"

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    2-Arylnaphthoquinone analogues: Potential anti-TB and pro-apoptotic agents
    (Green, I. R. et al. (2011). 2-Arylnaphthoquinone analogues: Potential anti-TB and pro-apoptotic agents. ARKIVOC, (x), 192-212. https://doi.org/10.3998/ark.5550190.0012.a16, 2011) Green, Ivan R; Sagar, Sunil; Swigelaar, Wendell
    A useful library of substituted 2-arylnaphthoquinones prepared by reaction between the corresponding bromonaphthoquinones and arylboronic acids via Suzuki-Miyaura protocols has been established. Conversion of some of the products into new analogues was effected. The bisnaphthoquinone disospyrin 1 comprises two 7-methyljuglone units linked between C2 and C6. 1,2 Antimycobacterial activity studies performed on diospyrin 1 alerted the scientific community to the potential importance of this natural product3 which was soon followed by its first published synthesis by Yoshida and Mori in the same year.4 Subsequent studies, which included the synthesis and evaluation of related analogues of diospyrin 1 demonstrated the potential of this basic scaffold to be considered as an integral aspect for good antimycrobacterial activity.
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    DDESC: Dragon database for exploration of sodium channels in human
    (BMC Cancer, 2008) Sagar, Sunil; Kaur, Mandeep; Dawe, Adam; Seshadri, Sundararajan V.; Christoffels, Alan; Schaefer, Ulf; Radovanovic, Aleksander; Bajic, Vladimir B.
    Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic disorders such as febrile epilepsy, Brugada syndrome, ventricular fibrillation, long QT syndrome, or channelopathy associated insensitivity to pain. In spite of these significant effects that sodium channel proteins/genes could have on human health, there is no publicly available resource focused on sodium channels that would support exploration of the sodium channel related information. We report here Dragon Database for Exploration of Sodium Channels in Human (DDESC), which provides comprehensive information related to sodium channels regarding different entities, such as "genes and proteins", "metabolites and enzymes", "toxins", "chemicals with pharmacological effects", "disease concepts", "human anatomy", "pathways and pathway reactions" and their potential links. DDESC is compiled based on text- and data-mining. It allows users to explore potential associations between different entities related to sodium channels in human, as well as to automatically generate novel hypotheses. DDESC is first publicly available resource where the information related to sodium channels in human can be explored at different levels.