Browsing by Author "Rahman, Ziyaad"

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    The effects of doxorubicin loaded chitosan-alginate nanoparticles on SK-N-BE(2) neuroblastoma cells
    (University of the Western Cape, 2022) Rahman, Ziyaad; Hiss, Donavon
    Cancer is a life-threatening disease and one of the leading causes of death globally. Cancer was thought to be associated with developed countries only but it is increasingly becoming a major health challenge in developing countries, including South Africa. Neuroblastoma is a form of cancer that affects the very early forms of nerve cells and is the most common extra-cranial solid tumour in children. It develops mainly in the adrenal medulla and the sympathetic ganglia. The focus of the present study is the development of a doxorubicin-loaded nanoparticle drug delivery system for the treatment of neuroblastoma. The biological diversity of the neuroblastic tumours that occur in patients has led to a divided approach in therapeutic strategies. Recent research efforts are aimed at designing therapies that will exploit the key oncogenic features of tumours, either within the tumours, in the tumour microenvironment, or both. Although doxorubicin chemotherapy is known to be generally very effective, previous studies have shown that it may result in the undesired toxicity of cardiomyocytes, cardiac fibroblasts, cardiac progenitor cells, endothelial progenitor cells, smooth muscle cells, and mesenchymal stem cells.
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    Visual technologies and the shaping of public memory of disappeared persons in Cape Town (1960-1990)
    (University of the Western Cape, 2021) Rahman, Ziyaad; Hayes, Patricia
    The starting point of this thesis is the work of the Truth and Reconciliation Commission (TRC) and the Missing Person�s Task Team (MPTT), two instruments of the post-apartheid government, both of which have directly attended to the disappeared dead. The disappeared dead are defined in this thesis as persons abducted and subject to enforced disappearances, as well as those killed in other political circumstances whose bodies were buried by the apartheid state, in some cases as unnamed paupers, thus denying families the opportunity to bury and mourn according to familial or cultural norms. Today the MPTT still seeks to locate the gravesites of the disappeared dead, to exhume, identify and to return the mortal remains to their families.