Browsing by Author "Opuwari, Chinyerum S."

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    Green tea consumption increases sperm concentration and viability in male rats and is safe for reproductive, liver and kidney health
    (Springer Nature, 2020) Opuwari, Chinyerum S.; Monsees, Thomas Klaus
    Green tea is a popularly consumed beverage worldwide and contains polyphenols, whose antioxidant activities could improve sperm parameters and fertility thereof. We investigated the effect of green tea on the male rat reproductive system as well as its safety. Male Wistar rats were administered 2 and 5% aqueous extract of green tea for 52 days’ ad libitum, while the control group received tap water. Total polyphenol, flavanol, flavonol and soluble solids significantly increased in a concentration-dependent manner in vitro (P < 0.01). Weights of body, testis, epididymis, prostate gland, seminal vesicles, and liver, serum levels of testosterone, ferric reducing antioxidant power, creatinine, and sperm motility, remained unchanged (P > 0.05).
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    The role of hyperglycaemia, oxidative stress, and inflammation in diabetes-related male infertility: therapeutic properties of medicinal plants
    (Shahrekord University of Medical Sciences, 2025) Opuwari, Chinyerum S.; Nethengwe, Murendeni; Okaiyeto, Kunle; Oguntibeju, Oluwafemi O.
    The prevalence of diabetes mellitus (DM) continues to rise at an alarming rate. DM leads to a decline in male reproductive function. Hyperglycaemia is an instigator of both oxidative stress and inflammation in the male reproductive system. The presence of excessive reactive oxygen species (ROS) and inflammatory markers in the semen of diabetic individuals results in the decline of sperm parameters. Despite ongoing advancements in the treatment of DM with conventional drugs, concern about treatment costs and side effects is high. Scientific research focus has therefore shifted to investigating naturally occurring safer, cheaper, and more effective treatments. This review outlined the link between hyperglycaemia and diabetic complications, and the role of oxidative stress and inflammation in the development of male infertility. We also reviewed the effects of phytochemicals in medicinal plants in treating DM-related male infertility. This review concluded that oxidative stress and inflammation are instigators of the decline in sperm parameters in diabetic conditions. The administration of medicinal plant extracts with hypoglycaemic, anti-diabetic, antioxidative, and anti-inflammatory properties can potentially restore diabetic-related male reproductive dysfunction.