Browsing by Author "Ongole, Joven Jebio"

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    Cross-sectional study of prevalence and determinants of uncontrolled hypertension among South African adult residents of Mkhondo municipality
    (Springer Nature, 2020) Masilela, Charity Mandisa; Pearce, Brendon; Ongole, Joven Jebio
    Achieving the blood pressure treatment target in individuals with hypertension is a serious global health challenge. Furthermore, the actual burden of uncontrolled hypertension is poorly understood, especially in the developing countries. Therefore, this study comprehensively examined the prevalence and factors associated with uncontrolled hypertension in individuals receiving care at the primary healthcare facilities in the rural areas of Mkhondo Municipality in the Mpumalanga Province, South Africa. Methods: In this cross-sectional study, 329 individuals attending care for hypertension were recruited from January 2019 to June 2019 at three primary healthcare centres, namely, Piet Retief hospital, Mkhondo town clinic and Thandukukhanya community health centre.
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    Factors associated with glycemic control among South African adult residents of Mkhondo municipality living with diabetes mellitus
    (Lippincott, Williams & Wilkins, 2020) Masilela, Charity; Pearce, Brendon; Ongole, Joven Jebio
    This study examines the rate and the influencing factors of glycemic control among adult residents living with DM in Mkhondo Municipality of South Africa. In this cross-sectional study, 157 individuals attending care for DM were recruited. Glycemic control status was categorized as poor if glycated hemoglobin (HbA1c) > 7% and very poor if HbA1c ≥ 9%. Multivariate regression analysis was used to identify the significant determinants of poor and very poor glycemic control. The majority of the study participants were females (84.71%) and above 45 years old (88.55%). The overall prevalence of poor glycemic control was 77.71% (n=122), while very poor glycemic control occurred in 50.6% (n=80) of the study cohort. In the multivariate logistic regression model analysis, African traditional [AOR=0.15; 95% confidence interval (95% CI) 0.04–0.57], fast food consumption (AOR=5.89; 95% CI 2.09–16.81), elevated total cholesterol (TC) [odds ratio (OR)=2.33; 95% CI 1.50–5.17], elevated low-density lipoprotein cholesterol (LDL-C) (AOR=5.28; 95% CI 1.89–14.69), and triglyceride (TG) (AOR=4.39; 95% CI 1.48–13.00) were the independent and significant determinants of poor glycemic control. Age (AOR=0.46; 95% CI 0.23–0.92) was the only independent and significant determinant of very poor glycemic control. We found a high rate of poor glycemic control (77.71%) possibly attributed to religious affiliation, fast food consumption, and dyslipidemia. On the contrary, about half of the study sample had very poor glycemic control (HbA1c ≥9%), which was predominant among younger cohort with diabetes mellitus. Interventions aimed at improving glycemic control in this population must also target religious practice, dietary patterns and dyslipidemia as well as tailored-approach for young people.
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    Genomic association of single nucleotide polymorphisms with blood pressure response to hydrochlorothiazide among south african adults with hypertension
    (MDPI, 2020) Masilela, Charity Mandisa; Pearce, Brendon; Ongole, Joven Jebio
    : This study described single nucleotide polymorphisms (SNPs) in hydrochlorothiazideassociated genes and further assessed their correlation with blood pressure control among South African adults living with hypertension. A total of 291 participants belonging to the Nguni tribes of South Africa on treatment for hypertension were recruited. Nineteen SNPs in hydrochlorothiazide pharmacogenes were selected and genotyped using MassArray. Uncontrolled hypertension was defined as blood pressure ≥140/90 mmHg. The association between genotypes, alleles and blood pressure response to treatment was determined by conducting multivariate logistic regression model analysis. The majority of the study participants were female (73.19%), Xhosa (54.98%) and had blood pressure ≥140/90 mmHg (68.73%). Seventeen SNPs were observed among the Xhosa tribe, and two (rs2070744 and rs7297610) were detected among Swati and Zulu participants.