Browsing by Author "Mthembu, Zandile Lorraine"

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    Studies of chemical constituents on the aerial parts of pelargoniumcapitatum
    (University of the Western Cape, 2017) Mthembu, Zandile Lorraine; Mabusela, Wilfred
    Pelargonium capitatum is a plant that is popular in essential oils. The isolated essential oil constituents from the flowers and leaves of the plant were obtained by hydrodistillation followed by GC-MS analysis. The following essential constituents were obtained in abundance from flowers and leaves 8, 11-octadecadienoic acid and citronellol, caryophyllen, α-cubebene, copaene, azulene, pentacosane, 9, 12- octadecadienoic acid. Crude extracts from Pelargonium capitatum were fractionated through various chromatographic techniques in order to achieve satisfactory separations. Four compounds were characterized and the structural elucidation were unambiguously confirmed by spectroscopic methods including one and two-dimensional nuclear magnetic resonance and high resolution mass spectroscopy. The compounds were isolated from the ethyl acetate (2) and hexane (2) extracts, respectively. The four isolates were identified as quercetin, quercetin xylopyranoside, β-sitosterol and undecaprenol. The isolate and the different extracts were tested for cytotoxicity using brine shrimp lethality test. The results showed that quercetin and the extracts were active with hexane extract showed the highest cytotoxicity level of 1.5μg/ml. To the best of our knowledge quercetin xylopyranoside, β-sitesterol and undecaprenol compounds are reported for the first time from Pelargonium capitatum.