Browsing by Author "January, Jaymi Leigh"

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    Indium nanoparticulate-modified polyanilino-co-4-aminobenzoic acid amperometric sensor for the detection of lapatinib, a breast cancer drug.
    (University of the Western Cape, 2022) January, Jaymi Leigh; Ajayi, Rachel F.
    Lapatinib is a highly prescribed drug used in combination with other drugs to treat breast cancer. Due to drug toxicity-related side effects experienced by some patients, there is need to determine appropriate dosage for patients. A novel nanobiosensor for the determination of the biotransformation of a cancer drug (LAPA) was constructed with a co-polymer, poly(anilino-co-4-aminobenzoic acid) {poly(ANI-co-4-ABA)} coupled to ground coffee extract-based, green-synthesized indium nanoparticles (InNPs) to which cytochrome P450-3A4 (CYP3A4) enzyme was additionally attached onto a glassy carbon electrode. Polyaniline (PANI), 4-ABA, indium nanoparticles (InNPs), poly(ANI-co-4-ABA) and poly(ANI-co-4-ABA)/InNPs were synthesized and used as sensor materials. The x-ray diffraction (XRD) analysis indicated crystallinity (average crystallite size of 27.31 nm) and gave a sharp peak at 21.40 (211) that is indexed to indium metal.