Browsing by Author "Cwasi, Phelisa"

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    Organometallic improvement of some tuberculosis drugs
    (University of the Western Cape, 2023) Cwasi, Phelisa; Onani, Martin
    Metal-based drugs are preferred motifs that serve as major pharmacophores in bioactive compounds for a variety of diseases, including as tuberculosis (TB). Heterocyclic, Schiff bases, aliphatic amines and other ligands are among the many potential scaffolds in drug design. To contribute to the development of these drugs, we discovered the metal-based organometallic complexes that could potentially be effective against tuberculosis, which is a common bacterial infectious disease that is caused by the bacillus mycobacterium tuberculosis (Mtb). As the demand for new compounds with desired antibacterial properties has grown over the past few decades, interest in Schiff bases has also significantly increased. Thus, in this study, five Schiff base ligands namely {HL1 = (Z)-4-chloro-2-((phenylimino)methyl)phenol, HL2 = (Z)-4-chloro-2-((o-tolylimino)methyl)phenol, HL3 = (Z)-4-chloro-2-((ptolylimino) methyl)phenol, HL4 = (Z)-4-chloro-2-(((2,4- dimethylphenyl)limino)methyl)phenol and HL5 = (Z)-4-chloro-2-(((2,6- dimethylphenyl)limino)methyl)phenol} were synthesized and fully characterized and complexed with CuCl2 for the synthesis of copper (II) salicylaldimine compounds.